Chronic Endometritis (CE)
Chronic Endometritis (CE) is a persistent, low-grade inflammatory condition of the endometrial lining caused by abnormal bacterial colonization (e.g., Enterococcus, E. coli, Streptococcus). CE is often subclinical with no obvious symptoms. It significantly impairs endometrial receptivity and is strongly associated with recurrent implantation failure and recurrent pregnancy loss. Diagnosis requires office hysteroscopy (strawberry-pattern micropolypoid endometrium) confirmed by CD138 immunohistochemistry on endometrial biopsy. Treatment uses targeted antibiotics (typically doxycycline, amoxicillin, or based on culture). A cohort study found the biopsy and treatment group had significantly higher rates of pregnancy (HR 2.28) and live birth (HR 2.76) compared to hysteroscopy-only controls.12
Cited in this entry
- Treatment following hysteroscopy and endometrial diagnostic biopsy. https://onlinelibrary.wiley.com/doi/10.1111/aji.13482
- Chronic endometritis in women with recurrent pregnancy loss and recurrent implantation failure. https://pubmed.ncbi.nlm.nih.gov/26456229/
Discussed in
Research library
- Chronic Endometritis in Infertile Women: Impact of Untreated Disease, Plasma Cell Count and Antibiotic Therapy on IVF Outcome-A Systematic Review and Meta-Analysis
- Relationship between chronic endometritis and fallopian tube obstruction and its influence on pregnancy outcome after fallopian tubal recanalization
- The diagnosis of chronic endometritis in infertile asymptomatic women: a comparative study of histology, microbial cultures, hysteroscopy, and molecular microbiology
- Chronic endometritis: a combined histopathologic and clinical review of cases from 2002 to 2007
- Chronic Endometritis: Potential Cause of Infertility and Obstetric and Neonatal Complications
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