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Pediatrics, 58(4), 505-507, 1976

Urogenital tract abnormalities in sons of women treated with diethylstilbestrol

Benton B , Hart W , Brian E Henderson

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  • University of Southern California ROR
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Abstract

Since in utero exposure to diethylstilbestrol (DES) is known to cause abnormalities of the female genital tract later in life, exposed male offspring were located, surveyed by mail, and compared with unexposed male offspring from the same period and medical practices. The exposed and unexposed respondents appeared comparable and did not differ in their response to most medical questions. However, a larger proportion of exposed than of unexposed boys had experienced problems in passing urine (12.9% vs. 1.8%, P = .0003) and abnormalities of the penile urethra (4.4% vs. 0%; P = .017).

Topics

General OB/GYN > Prenatal Exposures > DiethylstilbestrolAndrology > Urogenital Abnormalities > DES ExposureReproductive Endocrinology > Endocrine Disruptors > Fetal Effects
diethylstilbestrol DES sons urogenital abnormalities, in utero DES exposure male offspring genital tract, Henderson DES male urogenital tract, prenatal estrogen exposure penile urethra abnormalities, DES exposed males urinary problems hypospadias, diethylstilbestrol male reproductive tract malformations, endocrine disruptor fetal male genital development, DES in utero exposure sons long-term effects, prenatal synthetic estrogen male offspring survey, diethylstilbestrol intergenerational reproductive effects

Cite this article

Henderson, B. E., Benton, B., Cosgrove, M. D., Baptista, J., Aldrich, J. O., Townsend, D. E., Hart, W. R., & Mack, T. M. (1976). Urogenital tract abnormalities in sons of women treated with diethylstilbestrol. *Pediatrics*, *58*(4), 505-507.

Keywords

Abnormalities, Drug-Induced, Diethylstilbestrol/adverse Effects/therapeutic Use, Female, Fetus/drug Effects, Humans, Hypospadias/chemically Induced, Male, Pregnancy, Pregnancy Complications/drug Therapy, Sex Factors, Urethral Stricture/chemically Induced, Urogenital Abnormalities, Diethylstilbestrol

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