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Abstract

In summary, the luteal phase defect is a deficiency of corpus luteum progesterone steroidogenesis, either in amount or duration, or both. The clinical manifestations include either primary infertility or repeated first trimester abortions. The diagnosis can only be made clinically on the basis of a well-timed endometrial biopsy that is read histologically as 2 or more days out of phase with the next period in at least two cycles.

Topics

Reproductive Endocrinology > Luteal Phase > Luteal Phase DefectInfertility > Female Factor > Luteal Phase InsufficiencyDiagnostics > Endometrial Biopsy > Histologic Dating
luteal phase defect diagnosis endometrial biopsy, corpus luteum progesterone deficiency infertility, luteal phase insufficiency recurrent first trimester abortion, Jones GS luteal phase defect, endometrial biopsy out of phase luteal defect, progesterone steroidogenesis deficiency corpus luteum, luteal phase defect primary infertility miscarriage, histologic dating endometrium luteal insufficiency, clinical diagnosis luteal phase deficiency criteria, inadequate luteal phase progesterone duration
PMID 1269800 1269800 DOI 10.1016/s0015-0282(16)41769-3 10.1016/s0015-0282(16)41769-3

Cite this article

Jones, G. S. (1976). The luteal phase defect. *Fertility and sterility*, *27*(4), 351-356. https://doi.org/10.1016/s0015-0282(16)41769-3

Keywords

Abortion, Spontaneous/physiopathology/prevention & Control, Corpus Luteum/metabolism/physiopathology, Female, Humans, Hypothalamo-Hypophyseal System/physiopathology, Infertility, Female/drug Therapy/physiopathology, Pregnancy, Progesterone/biosynthesis/deficiency/therapeutic Use, Progesterone

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