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American journal of obstetrics and gynecology, 212(3), 375.e1-375.e11, 2015

The effect of a very short interpregnancy interval and pregnancy outcomes following a previous pregnancy loss

David Faraggi , Noya Galai , Anne M Lynch

Author affiliations (7)
  • University of Haifa ROR
  • University of Colorado Denver ROR
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development ROR
  • University of Utah ROR
  • Intermountain Healthcare ROR
  • Department of Epidemiology and Environmental Health, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY. ROR
  • Commonwealth Medical College ROR
DOI10.1016/j.ajog.2014.09.020 PMID25246378
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Abstract

Objective

We sought to assess the relationship between a short interpregnancy interval (IPI) following a pregnancy loss and subsequent live birth and pregnancy outcomes.

Study Design

A secondary analysis of women enrolled in the Effects of Aspirin in Gestation and Reproduction trial with a human chorionic gonadotropin-positive pregnancy test and whose last reproductive outcome was a loss were included in this analysis (n = 677). IPI was defined as the time between last pregnancy loss and last menstrual period of the current pregnancy and categorized by 3-month intervals. Pregnancy outcomes include live birth, pregnancy loss, and any pregnancy complications. These were compared between IPI groups using multivariate relative risk estimation by Poisson regression.

Results

Demographic characteristics were similar between IPI groups. The mean gestational age of prior pregnancy loss was 8.6 ± 2.8 weeks. The overall live birth rate was 76.5%, with similar live birth rates between those with IPI ≤3 months as compared to IPI >3 months (adjusted relative risk [aRR], 1.07; 95% confidence interval [CI], 0.98-1.16). Rates were also similar for periimplantation loss (aRR, 0.95; 95% CI, 0.51-1.80), clinically confirmed loss (aRR, 0.75; 95% CI, 0.51-1.10), and any pregnancy complication (aRR, 0.88; 95% CI, 0.71-1.09) for those with IPI ≤3 months as compared to IPI >3 months.

Conclusion

Live birth rates and adverse pregnancy outcomes, including pregnancy loss, were not associated with a very short IPI after a prior pregnancy loss. The traditional recommendation to wait at least 3 months after a pregnancy loss before attempting a new pregnancy may not be warranted.

Topics

PregnancyInfertility
interpregnancy interval pregnancy loss, short interval after miscarriage outcomes, EAGeR trial interpregnancy spacing, pregnancy loss subsequent live birth, conception timing after miscarriage, interpregnancy interval complications, rapid reconception after loss, pregnancy spacing fertility outcomes, miscarriage recovery conception timing
PMID 25246378 25246378 DOI 10.1016/j.ajog.2014.09.020 10.1016/j.ajog.2014.09.020

Cite this article

Wong, L. F., Schliep, K. C., Silver, R. M., Mumford, S. L., Perkins, N. J., Ye, A., Galai, N., Wactawski-Wende, J., Lynch, A. M., Townsend, J. M., Faraggi, D., & Schisterman, E. F. (2015). The effect of a very short interpregnancy interval and pregnancy outcomes following a previous pregnancy loss. *American journal of obstetrics and gynecology*, *212*(3), 375.e1-375.e11. https://doi.org/10.1016/j.ajog.2014.09.020

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