Risk of breast cancer associated with short-term use of oral contraceptives

Folger SG, Marchbanks PA, McDonald JA, Bernstein L, Ursin G, Berlin JA, Daling JR, Norman SA, Strom BL, Weiss LK, Simon MS, Burkman RT, Malone KE, Spirtas R

doi:10.1007/s10552-006-0086-7

Cancer Causes & Control : CCC, 18(2), 189-198, 2007

Risk of breast cancer associated with short-term use of oral contraceptives

Jesse A Berlin , Leslie Bernstein , Kathleen E Malone

Author affiliations (13)

Johnson & Johnson (United States) ROR
Centers for Disease Control and Prevention ROR
Wayne State University ROR
University of Oslo ROR
The Centers ROR
National Cancer Institute ROR
Division of Cancer Etiology, Department of Population Sciences, City of Hope Medical Center, Duarte, California; Departments of 2Preventive Medicine and 3Pathology, Keck School of Medicine, Univers... ROR
Division of Cancer Etiology, Department of Population Sciences, City of Hope Medical Center, Duarte, California; Departments of 2Preventive Medicine and 3Pathology, Keck School of Medicine, Univers...
University of Southern California ROR
Fred Hutch Cancer Center ROR
Baystate Medical Center ROR
University of Pennsylvania ROR
City Of Hope National Medical Center ROR

DOI10.1007/s10552-006-0086-7 PMID17216547

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Abstract

Objective

To estimate breast cancer risk associated with short-term (<6 months) oral contraceptive use, and explore variation in estimates by use characteristics and medical, menstrual, and reproductive history.

Methods

We analyzed data from the Women's Contraceptive and Reproductive Experiences Study. Case subjects were white women and black women, 35-64 years old, diagnosed with invasive breast cancer in July 1994-April 1998. Control subjects identified by random-digit dialing were matched to case subjects by age, race, and study site. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs).

Results

Overall, short-term oral contraceptive use was not associated with breast cancer risk (OR = 1.0; 95% CI = 0.8-1.1). However, significant interaction between short-term use and menopausal status led to an observed increased breast cancer risk in pre-menopausal women (OR = 1.3; 95% CI = 1.0-1.7) and a reduced risk in post-menopausal women (OR = 0.8; 95% CI = 0.6-1.0) associated with short-term use. The association was more pronounced in women with non-contraceptive reasons for use and underlying risk factors for breast cancer.

Conclusions

These associations may result from underlying characteristics of users or unmeasured factors influencing duration of use and breast cancer risk.

Topics

Contraception/Comparison > Oral Contraceptives > Cancer Risk General OB/GYN > Breast Cancer > Hormonal Risk Factors Research Methodology > Epidemiologic Design > Case-Control Study

short-term oral contraceptive use breast cancer risk, oral contraceptive duration breast cancer premenopausal women, hormonal contraception breast cancer case-control study, menopausal status oral contraceptive breast cancer interaction, Women's Contraceptive Reproductive Experiences Study breast cancer, oral contraceptive non-contraceptive use breast cancer risk, short duration pill use breast cancer odds ratio, premenopausal breast cancer risk oral contraceptive exposure, Folger Marchbanks oral contraceptive breast cancer, racial differences oral contraceptive breast cancer risk

PMID 17216547 17216547 DOI 10.1007/s10552-006-0086-7 10.1007/s10552-006-0086-7

Cite this article

Folger, S. G., Marchbanks, P. A., McDonald, J. A., Bernstein, L., Ursin, G., Berlin, J. A., Daling, J. R., Norman, S. A., Strom, B. L., Weiss, L. K., Simon, M. S., Burkman, R. T., Malone, K. E., & Spirtas, R. (2007). Risk of breast cancer associated with short-term use of oral contraceptives. *Cancer causes & control : CCC*, *18*(2), 189-198. https://doi.org/10.1007/s10552-006-0086-7

Keywords

Contraceptives, Oral

Risk of breast cancer associated with short-term use of oral contraceptives

Abstract

Topics

Cite this article

Keywords

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