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International Journal of Fertility, 32(3), 192-199, 1987

Progesterone therapy to decrease first-trimester spontaneous abortions in previous aborters

C H Wu , J H Check

Author affiliations (2)
  • Department of Obstetrics and Gynecology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
  • Cooper University Hospital ROR
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Abstract

A study was designed to see if the use of prophylactic progesterone vaginal suppositories (PVS) reduced the risk of spontaneous abortions in women with a history of at least one spontaneous abortion. PVS was employed during the luteal phase to the end of the first trimester. The dosage was initially 50 mg/day, but was increased according to the endometrial biopsy and doubled as soon as pregnancy was established. Only 10 women (10%) aborted, and 8 of these 10 were successful in their next PVS-treated pregnancies. Overall there were 12 losses in 132 pregnancies (9%) in these PVS-treated patients. Forty-two percent of untreated controls aborted (10/24). The results suggest that PVS is effective in reducing the risk of spontaneous abortions in high-risk patients.

Topics

Infertility > Recurrent Pregnancy Loss > Progesterone TherapyRRM Methods > Progesterone Supplementation > Vaginal SuppositoriesPregnancy > First Trimester > Miscarriage Prevention
progesterone vaginal suppositories recurrent spontaneous abortion prevention, prophylactic progesterone luteal phase miscarriage reduction, Check progesterone supplementation first trimester abortion prevention, luteal phase progesterone support habitual aborters pregnancy outcomes, progesterone suppositories endometrial biopsy miscarriage high risk, recurrent pregnancy loss progesterone therapy effectiveness, vaginal progesterone supplementation first trimester spontaneous abortion, luteal phase deficiency treatment progesterone previous aborters, progesterone dose adjustment endometrial biopsy pregnancy support, first trimester miscarriage prevention progesterone suppository therapy

Cite this article

Check, J. H., Chase, J. S., Nowroozi, K., Wu, C. H., & Adelson, H. G. (1987). Progesterone therapy to decrease first-trimester spontaneous abortions in previous aborters. *International journal of fertility*, *32*(3), 192-199.

Keywords

Abortion, Habitual/drug Therapy, Corpus Luteum Maintenance/drug Effects, Endometrium/cytology, Female, Humans, Pessaries, Pregnancy, Pregnancy Trimester, First, Progesterone/therapeutic Use, Progesterone

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