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Abstract

With the use of a rabbit surgical model, the ability of 1%, 2%, and 3% solutions of sodium carboxymethylcellulose to reduce postoperative uterine adhesions was determined. At all concentrations sodium carboxymethylcellulose was more effective than either 32% dextran 70 or heparinized lactated Ringer's solution. Neither the dextran nor Ringer's solution had a significant (p less than or equal to 0.05) effect. The beneficial effects of sodium carboxymethylcellulose were closely dose-dependent (correlation coefficient 0.97). Sodium carboxymethylcellulose is highly effective in reducing postoperative adhesions in laboratory animals, and additional studies are warranted to further define its efficacy and safety.

Topics

Surgery > Adhesion Prevention > Barrier AgentsSurgery > Animal Models > Adhesion Prevention StudiesGeneral OB/GYN > Surgical Complications > Postoperative Adhesions
sodium carboxymethylcellulose adhesion prevention rabbit model, postoperative adhesion prevention uterine surgery, adhesion barrier sodium carboxymethylcellulose dose dependent, dextran 70 Ringer solution adhesion prevention comparison, Fredericks postoperative adhesion prevention CMC solution, rabbit surgical model adhesion reduction barrier agents, pelvic adhesion prevention surgical adjuvant, carboxymethylcellulose concentration adhesion reduction efficacy, postoperative uterine adhesion prevention animal study, adhesion barrier heparinized lactated Ringer dextran comparison
PMID 2428251 2428251 DOI 10.1016/0002-9378(86)90304-2 10.1016/0002-9378(86)90304-2

Cite this article

Fredericks, C. M., Kotry, I., Holtz, G., Askalani, A. H., & Serour, G. I. (1986). Adhesion prevention in the rabbit with sodium carboxymethylcellulose solutions. *American journal of obstetrics and gynecology*, *155*(3), 667-670. https://doi.org/10.1016/0002-9378(86)90304-2

Keywords

Animals, Autopsy, Carboxymethylcellulose Sodium/administration & Dosage/therapeutic Use, Dextrans/administration & Dosage, Dose-Response Relationship, Drug, Female, Isotonic Solutions/administration & Dosage, Methylcellulose/analogs & Derivatives, Microsurgery/methods, Peritoneal Diseases/prevention & Control, Postoperative Complications/prevention & Control, Rabbits, Ringer's Lactate, Solutions, Tissue Adhesions/prevention & Control, Uterus/surgery, Dextrans, Isotonic Solutions, Ringer's Lactate, Solutions, Methylcellulose, Carboxymethylcellulose Sodium

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