Myo-Inositol
Myo-inositol is a naturally occurring carbocyclic sugar that functions as a secondary messenger in insulin signaling and follicle-stimulating hormone (FSH) pathways within ovarian tissue. Its role in reproductive physiology centers on insulin sensitization: disrupted inositol metabolism is a recognized feature of the insulin resistance seen across PCOS phenotypes, particularly Phenotypes A and B, where hyperandrogenism and metabolic dysfunction overlap.12
In women with PCOS, myo-inositol supplementation has been studied for its effects on menstrual cycle regularity, hormonal parameters, and ovarian function. Evidence supports improvements in LH-to-FSH ratios, reductions in androgen levels, and restoration of more regular ovulation in anovulatory patients.12
Myo-inositol has also been studied in the context of ovarian stimulation protocols, where it appears to support oocyte quality and metabolic markers.3 The available evidence base is strongest for metabolic and hormonal endpoints in PCOS; evidence for clinical pregnancy rate improvement is less consistent across studies, and no specific dose regimen is universally established.2
Cited in this entry
- Effect of Myo-Inositol in Treating Polycystic Ovary Syndrome (PCOS). https://respubjournals.com/obstetrics-gynecological-surgery/Effect-of-Myo-Inositol-in-Treating-Polycystic-Ovary-Syndrome-PCOS-A-Review.php
- The Effectiveness of Myo-Inositol in Women With Polycystic Ovary Syndrome. https://pmc.ncbi.nlm.nih.gov/articles/PMC10926319/
- Effect of myo-inositol supplementation in mixed ovarian response. https://pmc.ncbi.nlm.nih.gov/articles/PMC11968372/
Discussed in
Research library
- Comparison of myo-inositol and metformin on clinical, metabolic and genetic parameters in polycystic ovary syndrome: A randomized controlled clinical trial
- Randomized, double blind placebo-controlled trial: effects of myo-inositol on ovarian function and metabolic factors in women with PCOS
- Myo-inositol supplementation to prevent gestational diabetes in overweight non-obese women: bioelectrical impedance analysis, metabolic aspects, obstetric and neonatal outcomes - a randomized and open-label, placebo-controlled clinical trial
- Myo-inositol Supplementation for Prevention of Gestational Diabetes in Obese Pregnant Women: A Randomized Controlled Trial
- Myo-inositol may prevent gestational diabetes onset in overweight women: a randomized, controlled trial
This content is for educational purposes only and does not constitute medical advice. Consult an RRM clinician or healthcare provider for guidance specific to your situation.