Endometrial Thickness
Endometrial thickness is the measurement of the uterine lining obtained by transvaginal ultrasound, assessed at defined points in the menstrual cycle to evaluate implantation potential. A trilaminar (three-layer) pattern in the preovulatory phase indicates coordinated estrogen stimulation of the endometrium. Thickness below an adequate preovulatory range is associated with reduced implantation potential, though exact thresholds vary by population and cycle type.1
Causes of thin endometrium include prior uterine instrumentation (dilation and curettage, hysteroscopic procedures), intrauterine adhesions (Asherman syndrome), estrogen deficiency, reduced uterine blood flow, and chronic infection. When the clinician identifies thin endometrium, the question is: why? Measurement alone does not answer that question.
Endometrial assessment belongs alongside ovulation timing, hormonal evaluation, and uterine cavity evaluation, not as a standalone number. A normal thickness does not exclude poor receptivity, and low thickness may resolve when the underlying hormonal or anatomic cause is addressed. The window of implantation depends on more than thickness alone, including progesterone-driven secretory transformation of the endometrium after ovulation.
Cited in this entry
- Optimizing natural fertility: a committee opinion. https://rrmacademy.org/library/optimizing-natural-fertility-a-committee-opinion-rechyu5vnvihyqdwy/
Discussed in
Research library
- The effect of consecutive cycles of clomiphene citrate therapy on endometrial thickness and echo pattern
- The effect of clomiphene citrate on follicular phase increase in endometrial thickness and uterine volume
- Is endometrial thickness associated with fertility outcomes in intrauterine insemination? a cohort study
- Effects of clomiphene citrate on the endometrial thickness and echogenic pattern of the endometrium
- Tamoxifen is Better than Low-Dose Clomiphene or Gonadotropins in Women with Thin Endometrium (<7 mm) after Clomiphene in Intrauterine Insemination Cycles: A Prospective Study
This content is for educational purposes only and does not constitute medical advice. Consult an RRM clinician or healthcare provider for guidance specific to your situation.